Alzheimer's Disease

Recent clinical trials for treating Alzheimer’s Disease (AD) have achieved reduction of amyloid burden but this has not resulted in cognitive improvement. Thus, many AD investigators believe that the pathological processes must be attacked before the cognitive phenotype is manifest, while damage is still reversible or can be minimized1. In this context, the development of predictive biomarkers and models is critical for identifying patients with high risk of rapid progression along the AD continuum, i.e. transitioning from normal cognition to mild cognitive impairment (MCI) and from MCI to dementia. Emory Brain Imgaging Project is a component of the Emory Healthy Brain Study . It is jointly led by Drs Deqiang Qiu and Bruce Crosson and aims to develop imaging biomarkers that can predict the risk of conversion.

Stroke Imaging

Stroke is the fifth learding cause of death, and the leading cause of adult disability in the U.S. Imaging plays an important role in the management of acute stroke. We are interested in developing imaging methods in stratifying risks of secondary stroke among patients with stenosis or occlusion of carotid or intracranial arteries. Our strategy to addressing this problem is through measurement of cerebrovascular reactivity using both Acetozolamide and CO2 gas challenge as vasodilatory stimuli and novel MRI imaging techniques.

Diamox CVR

Machine Learning

Machine learning, particularly with the recent popularity of deep convolutional neural networks, has become a powerful tool for many areas, we have started working on using ML for image reconstruction, segmentation as well as disease diagosis and prognosis.

Chen S, Qi K, Qiu D. Is MRI all we need? Prediction of conversion between normal cognitive function, mild cognitive impairment and Alzheimer’s disease. Proceeding of International Society of Magnetic Resonance in Medicine 26th Annual meeting. June 2018

Cerebrovascular Reactivity

Perfusion and Blood Brain Barrier imaging

The measurement of cerebral blood flow, cerebral blood volume as well as cerebral permeability provides important insights into different neurological diseases, including tumor, multiple sclerosis, and Alzheimer's Disease. We have developed a novel multi-band multi-echo EPI (M2-EPI) sequence for simulateneous perfusion (CBF, CBV) and permeability imaging.

M2-EPI

Wu J, Saindane AM, Zhong X, Qiu D. Simultaneous perfusion and permeability assessments using multiband multi-echo EPI (M2-EPI) in brain tumors. Magn Reson Med. 2018 Oct 9. doi: 10.1002/mrm.27532.

Magnetic Susceptibility imaging

Quantitative susceptibility mapping is MR imaging technqiue that provides semi-quantitative measure of magnetic susceptibility values of tissues. In the brain, the primary source of magnetic susceptibility contrast comes from iron content, myelin and deoxygenated hemoglobin. We have used susceptibility imaging to measure oxygenation extraction fraction with and without Acetozolamide in patients with cerebrovascular disease

QSM OEF

Leatherday C, Dehkharghani S, Nahab F, Allen JW, Wu J, Hu R, Qiu D. Cerebral MR oximetry during acetazolamide augmentation: Beyond cerebrovascular reactivity in hemodynamic failure. JMRI. 2018